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The 100 Most Disruptive Pouch Papers

Ranked by the disruption index (CD index; Funk & Owen-Smith 2017), a citation-network measure of how strongly a paper eclipses the prior work it builds on rather than reinforcing it. Computed locally from the NIH Open Citation Collection across the pouch (IPAA & continent-ileostomy) literature.

#PaperCD index
1Total colectomy and ileorectal anastomosis in diffuse ulcerative colitis.
AYLETT · 1957 · Br Med J
+0.703
34 cites
2Three hundred cases of diffuse ulcerative colitis treated by total colectomy and ileo-rectal anastomosis.
Aylett · 1966 · Br Med J
+0.636
137 cites
3Laparoscopic total proctocolectomy with creation of ileostomy for ulcerative colitis: report of two cases.
Peters · 1992 · J Laparoendosc Surg
+0.496
63 cites
4Ulcerative colitis treated by total colectomy and ileorectal anastomosis: a ten-year review.
AYLETT · 1963 · Proc R Soc Med
+0.424
39 cites
5Proctocolectomy without ileostomy for ulcerative colitis.
Parks A · 1978 · Br Med J
+0.400
1,023 cites
6Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous Polyposis
Burke · 2020 · N Engl J Med
+0.371
53 cites
7Ulcerative colitis with relative sparing of the rectum. Clinical features, histology, and prognosis.
Spiliadis · 1987 · Dis Colon Rectum
+0.356
48 cites
8Ileostomy for ulcerative colitis; technique, complications, and management.
WARREN · 1951 · Surg Gynecol Obstet
+0.314
136 cites
9Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease.
Hellers · 1980 · Gut
+0.292
362 cites
10Life expectancy after colectomy and ileorectal anastomosis for familial adenomatous polyposis.
Nugent · 1993 · Dis Colon Rectum
+0.270
145 cites
11An Update on the Medical Management of Inflammatory Pouch Complications
Quinn · 2020 · Am J Gastroenterol
+0.221
29 cites
12Predicting Outcomes in Pediatric Ulcerative Colitis for Management Optimization: Systematic Review and Consensus Statements From the Pediatric Inflammatory Bowel Disease-Ahead Program.
Orlanski-Meyer · 2021 · Gastroenterology
+0.218
46 cites
13Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in long-standing ulcerative colitis: an indication for colectomy.
Blackstone · 1981 · Gastroenterology
+0.207
412 cites
14Treatment of colorectal and ileoanal anastomotic sinuses
Whitlow · 1997 · Dis Colon Rectum
+0.166
55 cites
15Comparison of handsewn with stapled loop ileostomy closures
Hull · 1996 · Dis Colon Rectum
+0.161
58 cites
16Course of ulcerative colitis: analysis of changes in disease activity over years.
Langholz · 1994 · Gastroenterology
+0.142
523 cites
17Repair of persistent perineal sinuses by means of a pedicle flap of musculus gracilis. Case report.
Bartholdson · 1975 · Scand J Plast Reconstr Surg
+0.135
41 cites
18The treatment of acute toxic ulcerative colitis by ileostomy and simultaneous colectomy.
CRILE · 1951 · Gastroenterology
+0.130
50 cites
19Quality of life after prophylactic colectomy and ileorectal anastomosis in patients with familial adenomatous polyposis
Church · 1996 · Dis Colon Rectum
+0.124
53 cites
20Fate of the rectal mucosa after rectal mucosectomy and ileoanal anastomosis.
Heppell · 1983 · Dis Colon Rectum
+0.121
105 cites
21Short-chain fatty acids in the human colon: relation to gastrointestinal health and disease
Mortensen · 1996 · Scand J Gastroenterol Suppl
+0.118
332 cites
22Portal bacteraemia in cases of ulcerative colitis submitted to colectomy.
Eade · 1969 · Lancet
+0.118
90 cites
23An innovative technique for colorectal specimen retrieval: a new era of "natural orifice specimen extraction" (N.O.S.E)
Palanivelu · 2008 · Dis Colon Rectum
+0.117
112 cites
24Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications.
Riddell · 1983 · Human pathology
+0.113
1,579 cites
25Cyclosporine in severe ulcerative colitis refractory to steroid therapy.
Lichtiger · 1994 · N Engl J Med
+0.110
1,416 cites
26Serum antibodies to Bacteroides species in chronic inflammatory bowel disease.
Tvede · 1983 · Scand J Gastroenterol
+0.109
42 cites
27Mortality in patients with familial adenomatous polyposis.
Arvanitis · 1990 · Dis Colon Rectum
+0.105
324 cites
28Subtotal colectomy for ulcerative colitis: complications related to the rectal remnant.
Carter F · 1991 · Dis Colon Rectum
+0.101
75 cites
29The extra-intestinal complications of Crohn's disease and ulcerative colitis: a study of 700 patients.
Greenstein · 1976 · Medicine (Baltimore)
+0.099
1,060 cites
30Social prognosis in patients with ulcerative colitis.
Hendriksen · 1980 · Br Med J
+0.097
51 cites
31Single-patient randomised clinical trial. Use in determining optimum treatment for patient with inflammation of Kock continent ileostomy reservoir
McLeod · 1986 · Lancet
+0.093
67 cites
32Primary closure of perineal wound after proctocolectomy or rectal excision.
Hultén · 1971 · Acta Chir Scand
+0.093
36 cites
33Laparoscopically assisted ileocolectomy in Crohn's disease.
Milsom · 1993 · Surg Laparosc Endosc
+0.091
77 cites
34Composite resection and reconstruction for oral cavity and oropharynx cancer. A functional approach.
LaFerriere K · 1980 · Arch Otolaryngol
+0.091
32 cites
35Inflammatory bowel disease.
Hyams Jeffrey · 2005 · Pediatr Rev
+0.084
26 cites
36A repair operation for recurrent dislocation of peroneal tendons.
Das De · 1985 · J Bone Joint Surg Br
+0.082
59 cites
37Paradoxical puborectalis contraction in patients after pelvic pouch construction
Hull · 1995 · Dis Colon Rectum
+0.080
26 cites
38Laparoscopic surgery for inflammatory bowel disease
Liu · 1995 · Am Surg
+0.078
45 cites
39Unexplained bronchopulmonary disease with inflammatory bowel disease.
Kraft · 1976 · Arch Intern Med
+0.073
200 cites
40Pregnancy after ileostomy for chronic ulcerative colitis.
SCUDAMORE · 1957 · Gastroenterology
+0.072
22 cites
41Fecal Microbiota Transplant for Recurrent Clostridium difficile Infection in Pediatric Inflammatory Bowel Disease.
Cho · 2019 · J Pediatr Gastroenterol Nutr
+0.071
22 cites
42Results of surgery for inflammatory bowel disease: a further survey of one hospital region.
Ritchie · 1974 · Br Med J
+0.069
53 cites
43Regression of rectal adenomas after colectomy and ileorectal anastomosis for familial adenomatous polyposis.
Nicholls · 1988 · Br Med J
+0.069
43 cites
44Effect of neostigmine on integrity of ileorectal anastomoses.
Bell · 1968 · Br Med J
+0.066
57 cites
45The role of laparoscopic surgery in the management of children and adolescents with inflammatory bowel disease.
Page · 2015 · Medicine (Baltimore)
+0.064
38 cites
46The fate of the rectal stump after subtotal colectomy for ulcerative colitis.
Oakley · 1985 · Dis Colon Rectum
+0.062
47 cites
47Clinical outcome and bowel function following total abdominal colectomy and ileorectal anastomosis in the Oriental population.
Eu · 1998 · Dis Colon Rectum
+0.060
35 cites
48Clinical outcome of ulcerative colitis in children.
Hyams · 1996 · J Pediatr
+0.058
125 cites
49An assessment of inflammation in the reservoir after restorative proctocolectomy with ileoanal ileal reservoir
Moskowitz · 1986 · Int J Colorectal Dis
+0.058
299 cites
50Safety of the temporary loop ileostomy
Hallböök · 2002 · Colorectal Dis
+0.056
62 cites
51PLACE OF A DOUBLE-BARRELLED ILEOSTOMY IN ULCERATIVE COLITIS AND CROHN'S DISEASE OF THE COLON: A PRELIMINARY REPORT.
TRUELOVE · 1965 · Br Med J
+0.056
66 cites
52Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.
Ng · 2017
+0.056
4,514 cites
53Adenocarcinoma of the ileostomy occurring after colectomy for ulcerative colitis: report of a case.
Sigler · 1969 · Dis Colon Rectum
+0.055
58 cites
54Endosonographic differentiation of mucosal and transmural nonspecific inflammatory bowel disease
Hildebrandt · 1992 · Endoscopy
+0.054
36 cites
55Prospective study of the effect of resection of the rectum on male sexual function
Fazio · 1980 · World J Surg
+0.052
77 cites
56Non-specific ulcerative colitis, with reference to mortality, morbidity, complications and long-term survivals following colectomy.
BACON · 1956 · Am J Surg
+0.052
24 cites
57Fluorescence angiography during transanal trans-stomal proctectomy and ileal pouch anal anastomosis: a video vignette
Spinelli · 2017 · Colorectal Dis
+0.051
21 cites
58Laparoscopic total abdominal colectomy. A prospective trial
Wexner · 1992 · Dis Colon Rectum
+0.050
191 cites
59Let sleeping dogs lie: role of the omentum in the ileal pouch-anal anastomosis procedure
Ambroze · 1991 · Dis Colon Rectum
+0.050
40 cites
60Optum Labs: building a novel node in the learning health care system.
Wallace Paul · 2014 · Health Aff
+0.050
350 cites
61Rehabilitation and long-term survival after colectomy for ulcerative colitis.
BACON · 1960 · JAMA
+0.050
23 cites
62Syndrome of duodenal compression by the superior mesenteric artery following restorative proctocolectomy: a case report and review of literature
Matheus Cde · 2005 · Sao Paulo Med J
+0.049
21 cites
63A surgical subspecialist enhances general surgical operative experience
Galandiuk · 1995 · Arch Surg
+0.049
25 cites
64Ileal pouch-anal anastomosis without temporary, diverting ileostomy
Metcalf · 1986 · Dis Colon Rectum
+0.047
54 cites
65Mucosal morphology, bacteriology, and absorption in intra-abdominal ileostomy reservoir.
Philipson · 1975 · Scand J Gastroenterol
+0.047
82 cites
66Long term prognosis in ulcerative colitis--based on results from a regional patient group from the county of Copenhagen.
Hendriksen · 1985 · Gut
+0.047
219 cites
67Portal hypertension and bleeding ileal varices after colectomy and ileostomy for chronic ulcerative colitis.
Cameron · 1970 · Gut
+0.046
49 cites
68Results of the pelvic-pouch procedure in patients with Crohn's disease.
Deutsch A · 1991 · Dis Colon Rectum
+0.044
132 cites
69Laparoscopic total abdominal colectomy with ileorectal anastomosis for familial adenomatous polyposis.
Milsom · 1997 · Dis Colon Rectum
+0.043
53 cites
70Centralized registration, prophylactic examination, and treatment results in improved prognosis in familial adenomatous polyposis. Results from the Danish Polyposis Register.
Bülow · 1995 · Scand J Gastroenterol
+0.039
76 cites
71Probiotics, immunomodulation, and health benefits
Gill · 2008 · Adv Exp Med Biol
+0.039
123 cites
72Antibiotics for inflammatory bowel disease: do they work?
Guslandi · 2005 · Eur J Gastroenterol Hepatol
+0.039
37 cites
73Overlap in the spectrum of non-specific inflammatory bowel disease--'colitis indeterminate'.
Price · 1978 · J Clin Pathol
+0.037
264 cites
74Prognosis after surgery for colonic Crohn's disease.
Andrews H · 1989 · Br J Surg
+0.036
54 cites
75Review article: short chain fatty acids in health and disease
Cook · 1998 · Aliment Pharmacol Ther
+0.034
396 cites
76Relationship of backwash ileitis to ileal pouchitis after ileal pouch-anal anastomosis
Gustavsson · 1987 · Dis Colon Rectum
+0.033
71 cites
77Comparison of bowel function after ileorectal anastomosis for ulcerative colitis and colonic polyposis.
Newton · 1975 · Gut
+0.033
62 cites
78Pouchitis associated with primary cytomegalovirus infection
Moonka · 1998 · Am J Gastroenterol
+0.030
67 cites
79Patient characteristics associated with venous thromboembolic events: a cohort study using pooled electronic health record data.
Kaelber David · 2012 · J Am Med Inform Assoc
+0.030
112 cites
80Changes in the bidirectional sodium flux across the intestinal mucosa in Crohn's disease.
Allan · 1975 · Gut
+0.030
47 cites
81Predicting the functional result of anastomoses to the anus: the paradox of preoperative anal resting pressure
Church · 1993 · Dis Colon Rectum
+0.029
26 cites
82Long-term ileostomy complications in patients with ulcerative colitis and Crohn's disease.
Carlstedt · 1987 · Int J Colorectal Dis
+0.029
57 cites
83Tubulovillous adenomas in a continent ileostomy after proctocolectomy for familial polyposis
Beart · 1982 · Dig Dis Sci
+0.029
42 cites
84Ulcerative colitis treated by ileostomy and excisional surgery. Fifteen years' experience at St. Mark's Hospital.
Ritchie · 1972 · Br J Surg
+0.026
85 cites
85Surgical management of pseudomembranous colitis.
Bradley S · 1988 · Am Surg
+0.026
25 cites
86Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study
Becker · 1996 · J Am Coll Surg
+0.026
543 cites
87Life-table analysis of stomal complications following ileostomy.
Leong · 1994 · Br J Surg
+0.026
130 cites
88Is complete laparoscopic colectomy superior to laparoscopic assisted colectomy?
Bernstein · 1996 · Am Surg
+0.025
45 cites
89Filiform polyposis of the colon. First report in a case of transmural colitis (Crohn's disease).
Spark · 1976 · Am J Dig Dis
+0.025
21 cites
90Absorption of an oral contraceptive gestagen in ulcerative colitis before and after proctocolectomy and construction of a continent ileostomy
Nilsson · 1985 · Contraception
+0.025
28 cites
91Mortality in ulcerative colitis.
Gyde · 1982 · Gastroenterology
+0.025
96 cites
92An enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion molecule-1, in the treatment of chronic, unremitting pouchitis
Miner · 2004 · Aliment Pharmacol Ther
+0.024
107 cites
93Usefulness of valproate sodium for treatment of incontinence after ileoanal anastomosis.
Kusunoki · 1990 · Surgery
+0.023
29 cites
94Ileostomy and excision of the large intestine for ulcerative colitis.
Daly · 1967 · Lancet
+0.023
56 cites
95Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort.
Frøslie · 2007 · Gastroenterology
+0.023
923 cites
96Gynaecological problems related to anatomical changes after conventional proctocolectomy and ileostomy
Wikland · 1990 · Int J Colorectal Dis
+0.023
61 cites
97From iatrogenic digestive perforation to complete anastomotic disunion: endoscopic stenting as a new concept of "stent-guided regeneration and re-epithelialization".
Amrani Laila · 2009 · Gastrointest Endosc
+0.022
49 cites
98Crohn's disease in the elderly
Tchirkow · 1983 · Dis Colon Rectum
+0.022
41 cites
99Pediatric ileal pouch-anal anastomosis: functional outcomes and quality of life
Stavlo · 2003 · J Pediatr Surg
+0.021
37 cites
100Afferent limb obstruction complicating ileal pouch-anal anastomosis
Read · 1997 · Dis Colon Rectum
+0.020
28 cites

* Disruption index (CD) is unreliable for papers published within the last 5 years (insufficient forward-citation window); such papers are excluded from this ranking. CD ranges from +1 (fully disruptive) to −1 (fully consolidating).

Educational and research-reference use only. Bibliometric analysis only; abstracts and full text are not reproduced. Disruption index computed from the NIH Open Citation Collection (NIH-OCC). Each entry links to its PubMed record.